When adjusted for the effect of tumor type, grade, stage and depth of invasion, high Jag1/Notch2/Notch3 (cluster 3) expression remained an unfavorable prognostic factor for DFS when compared to high Jag1 without Notch2/Notch3 (cluster 1) or when all 3 proteins were low (cluster 2), although these results were of marginal statistical significance (cluster 1 vs. 3, adjusted HR = 0.40, 95% CI 0.15–1.02, p = 0.055; cluster 2 vs. 3, adjusted HR = 0.40, 95% CI 0.15–1.07, p = 0.067). This evidence concerns the gene NOTCH2 and neoplasm.