The aim of this study was to determine the potential prognostic value of Hedgehog and Notch pathway aberrations in endometrial cancer and to examine their association with clinical outcome and other clinicopathological characteristics, including a panel of protein markers (ER, PgR, HER2, Ki67, p53, p16, PTEN and mismatch repair [MMR] proteins) that had previously been implicated in the pathogenesis of endometrial cancer or had demonstrated significance as prognostic markers [17]. This evidence concerns the gene PTEN and endometrial cancer.