Ke B et al. showed that APS-regulated miR-721-PPAR-γ-PI3K/AKT-GLUT4 signaling pathway attenuates TNF-α-induced insulin resistance [32], emphasizing the role of miR-721 in the regulation of diabetes and suggesting miR-721 may be potential drug target for SHENQI compound. This evidence concerns the gene AKT1 and diabetes mellitus.