Previously, we reported that patients with PCa and a PSA level between 10 and 20 ng / mL at diagnosis had a more advanced stage of cancer than those with PCa and a PSA level between 3.5 and 10 ng / mL, whereas patients with PCa and a PSA level < 3.5 ng / mL at diagnosis potentially had a more advanced stage of cancer than those with PCa and a PSA level between 3.5 and 10 ng / mL (3). The gene discussed is KLK3; the disease is cancer.