1. Targeted deep sequencing analysis showed that TP53 (3/9 cases) and CTNNB1 (2/9 cases) were recurrent missense mutations in HCCs.2. Functional analysis of the β-catenin H36P mutant was observed to be resistant to protein degradation and to promote HCC cell proliferation. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.