1. The study reveals recurrent mutations in TP53, CTNNB1 and AXIN1, two genes (JAK1, LRPB1) commonly mutated in other cancers as well as six genes previously not reported.2. Pathways affected include Wnt, cytokine-induced JAK/STAT, G1/S cell cycle, and apoptosis. This evidence concerns the gene CTNNB1 and cancer.