1. Nine significantly mutated genes and cellular pathways such as p53, Wnt, PIK3/Ras, cell cycle, and chromatin remodeling account for ∼80% of the mutations identified in the 231 tumors.2. Genetic aberrations in the cell cycle pathway genes (RB1, MYC, CCND1, RBL2) were associated with cancer-specific and recurrence-free survival. Here, RB1 is linked to cancer.