1. A total of 4,314 somatic genomic rearrangement (GR) events were detected and annotated at the single-nucleotide resolution.2. Five HCC tumors harbored chromothripsis on chromosomal arms 1q, 8q, and 5p; 13 genes, including CEBPB, MCL1, and AXIN1, were significantly affected by GR. The gene discussed is CEBPB; the disease is hepatocellular carcinoma.