1. The study reveals recurrent mutations in TP53, CTNNB1 and AXIN1, two genes (JAK1, LRPB1) commonly mutated in other cancers as well as six genes previously not reported.2. Pathways affected include Wnt, cytokine-induced JAK/STAT, G1/S cell cycle, and apoptosis. The gene discussed is TP53; the disease is cancer.