1. cHCC/ICC and CoCC showing biliary epithelial differentiation (LCB) have recurrent mutations in the TERT promoter and chromatin regulators.2. Hepatitis-positive HCC and cHCC/CC had a larger frequency of TERT promoter mutations and a lower frequency of KRAS and IDH1/2 mutations than hepatitis-negative LCB. This evidence concerns the gene IDH1 and hepatocellular carcinoma.