TP53 and neoplasm: Using the observed average HER2 copy number (varied from 4 to 5.99) per tumor cell divided on a case-by-case basis by the corresponding observed average alternative control copy numbers demonstrated that ratios greater than or equal to 2.0 were observed for 61 cases using SMS, 65 using TP53, and 30 using D17S122 as the denominators in the HER2-to-control ratio calculations.