Furthermore, measurement by qRT-PCR on 9 months old Fam20C cKO mice showed significant increases in the re-expression of fetal gene markers of cardiac hypertrophy and heart failure, including atrial natriuretic factor (ANP), brain natriuretic peptide (BNP), and β-myosin heavy chain (β-MHC), in comparison to controls (Figure 5C). Here, NPPB is linked to cardiac hypertrophy.