In fact, by immunoblot analyses and quantifications of proteins from FACS-purified α6+CD34+ HF stem cells, P-cadherin levels in E-cadherin deficient HF stem cells were even higher than normal (Figure 1D and Figure 1—figure supplement 2C), a feature confirmed by knocking down Cdh1 transcripts through shRNA (Figure 1—figure supplement 2D). Here, TWF1 is linked to hydrops fetalis.