The next highest scoring hit is SIGLEC1/CD169 (Figure 5A), an HIV attachment factor that has been characterized to facilitate trans infection of CD4 +T cells by DCs through binding to sialylated glycosphingolipids on the HIV particle (Izquierdo-Useros et al., 2012; Puryear et al., 2013). The gene discussed is SIGLEC1; the disease is infection.