Infection of these cell pools with wt HIV-1LAI also shows significantly-increased virus release, suggesting that HIV-1LAI Vpu does not completely antagonize IFN-induced Tetherin in THP-1 cells (Tetherin_1 = 4.4 fold, Tetherin_2 = 2.14 fold in Figure 4F – right panel). The gene discussed is IFNA1; the disease is infection.