MxB, an interferon-induced GTPase that binds to and blocks lentiviral capsids, was identified as an IFNα-induced factor in THP-1 cells (Goujon et al., 2013; Haller et al., 2015; Kane et al., 2013; Liu et al., 2013), although the role of MxB in the IFNα-induced inhibition of HIV infection in these cells has been questioned (Opp et al., 2015). This evidence concerns the gene MX2 and HIV infectious disease.