In particular, analysis of IGHV unmutated CLL cases revealed additional non‐coding mutations in CLL driver genes such as IKZF3, SAMHD1, PAX5 and BIRC3. Finally, they found that IGHV unmutated CLL harbored coding mutations in driver genes, whereas IGHV‐mutated CLL harbored non‐coding promoter and enhancer mutations caused by aberrant AID activity (Burns et al., 2018). This evidence concerns the gene IKZF3 and B-cell chronic lymphocytic leukemia.