BCL2 and B-cell chronic lymphocytic leukemia: The notion that miR15a/16‐1 and BCL2 expression levels are inversely correlated in CLL, and that downregulation of miR15a/16‐1 results in an increase of B‐cell lymphoma 2 (BCL2) expression, with consequent inhibition of apoptosis, led to the identification of BCL2 as the primary target of miR15a/16‐1 (Table 1) (Cimmino et al., 2005; Cory and Adams 2002, 2005; Sanchez‐Beato et al., 2003).