Whole genome/exome sequencing (WES/WGS) studies in CLL revealed recurrently mutated driver genes such as NOTCH1, MYD88, TP53, ATM, SF3B1, FBXW7, POT1, CHD2, RPS15, IKZF3, ZNF292, ZMYM3, ARID1A and PTPN11 (Fabbri et al., 2011; Landau et al., 2015; Puente et al., 2011, 2015; Quesada et al., 2011; Ramsay et al., 2013; Rossi et al., 2012). The gene discussed is NOTCH1; the disease is B-cell chronic lymphocytic leukemia.