First, the magnitude of postprandial serum TG or plasma insulin levels estimated by the iAUC0−6 h after the fat load intake was higher in the MetS than in the control group, and the ezetimibe treatment reduced the postprandial hyperlipidemia and the hyperinsulinemia in the MetS group, but not in the control group. The gene discussed is INS; the disease is hyperlipidemia.