PPARA and cancer: Similarly, when a spatially distinct cancer sample (C0) or a low-quality sample (C3) was included as a representative of cancer tissue, the majority of top 300 downregulated genes were involved in ECM-associated proteins, whereas the other sample combinations showed that peroxisome proliferator-activated receptor (PPAR) signaling and/or cornification pathways were significantly downregulated in cancer tissues compared to adjacent normal tissues.