HMGB1 and neoplasm: Using chemotherapeutic agents, some types of cell death have been demonstrated to induce an immune response against antigens released from dying cells, commonly referred to as immunogenic cell death (ICD): the dying tumor cells can release a series of damage-associated molecular patterns (DAMPs), including calrectin (CRT) (24), adenosine triphosphate (ATP) (25), and high mobility group box 1 (HMGB1) (26), which plays an important role in the immune response elicited by ICD.