ATOH7 and open-angle glaucoma: Genes affecting optic nerve quantitative traits such as optic disc area and VCDR may have a plausible role in pathogenesis of POAG by affecting developmental-related pathways [20]. ATOH7 gene encodes Math5, a protein that plays a central role in RGC differentiation [4] and thus may not be a major risk modulator or causal factor in IOP-related pathogenesis of late-onset POAG.