With an estimated heritability of 0.81 [1], primary open angle glaucoma (POAG) follows a complex multi-factorial inheritance pattern involving both genetics and environmental factors [2]. Atonal bHLH transcription factor 7 (ATOH7), located on cytogenic band 10q21.3-22.1, is a single exon gene that encodes transcription factor known to play a central role in differentiation of retinal ganglion cells (RGCs) and optic nerve formation [3]. This evidence concerns the gene ATOH7 and glaucoma.