In the present study, we found that 6-G could reduce the ST section of I/R-induced electrocardiogram, improve cardiac function, shrink the area of MI, alleviate cardiac pathological injury, decrease the levels of markers of cardiac injury (cTnT and CK-MB), attenuate the level of serums inflammatory markers, TNF-a, IL-6, and IL-1β, and inhibit the expression of cardiac inflammatory markers, TNF-a, IL-6, IL-1β, NLRP3, and caspase-1. Here, NLRP3 is linked to myocardial infarction.