More researches have suggested that nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has participated in the pathophysiological process of MIRI, and inflammasome is a key factor that regulates IL-1β and activate caspase-1; inhibition of NLRP3 could shrink the area of myocardial infarction and the reconstruction of left ventricle following infarction [24, 25]. The gene discussed is IL1B; the disease is myocardial infarction.