In fact, growth factors like NGF, bFGF, and TGF-β1 implement their physiological functions under normal conditions; however, overexpression of NGF, bFGF, and TGF-β1 in the bladder, which is induced by BPH and BOO, evolves into a pathophysiological condition. This evidence concerns the gene TGFB1 and benign prostatic hyperplasia.