Genetic variations in OPTN and TBK1 were estimated to account for or contribute to 1.3% of cases in whole exome sequencing of 2,874 ALS patients (32), comparable to the contributions for those found in many other genes such as SOD1, TDP43, or C9ORF72 (33). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.