The cloned mutants include OPTNE478G, OPTNR96L, OPTNQ454E, OPTN382_383AGins, OPTNQ398X, OPTNQ165X, OPTNΔExon5 along with OPTNE50K, which was commonly mutated in open angle glaucoma, OPTNΔUBA with a deletion of ubiquitin binding domain(474-479aa), OPTNΔLIR with a deletion of LC3 interaction region(169-184aa). Here, MAP1LC3A is linked to open-angle glaucoma.