SIRT1 and Cerebral ischemia: Sirt1 is considered to be related to anti-inflammatory and anti-apoptotic effects in cerebral ischemia because its inhibition exacerbated ischemic injury accompanied by increased acetylation of p53 and NF-κB (nuclear factor-kappa B p65), which are important factors mediating inflammatory and apoptotic pathways causing brain damage (Hernandez-Jimenez et al., 2013).