To validate that DANCR/RXRA/PIK3CA signaling pathway regulates TNBC tumor growth, we down-regulated RXRA and overexpressed PIK3CA in MDA-MB-231 and MDA-MB-468 cells with a RXRA shRNA or a PIK3CA vector (Fig. 5g and Supplementary Figure 2A). The gene discussed is PIK3CA; the disease is neoplasm.