Indeed, Tg mice developed a rapid and lethal cachexia associated with systemic immune disorders: hematopoietic dysregulation (higher absolute number of mature CD11b+Ly6G+Ly6Clow/int and CD11b+Ly6G−Ly6Chigh cells), a systemic cytokine storm and massive infiltration of myeloid cells in several organs (Supplementary Fig. 3c–f), associated with a decrease in CD3+ T cells and preservation of T regulatory (Treg) lymphocytes (Supplementary Fig. 3g, h). Here, ITGAM is linked to immune system disorder.