We demonstrated that interference with NF-κB pathway was able to restrain partially the immunosuppressive activity as well as the PD-L1 expression in CD11b+Ly6C+ cells isolated from either BM of Tg mice (Supplementary Fig. 9d, e) or spleen of tumor-bearing wild-type mice (Fig. 5e, f and Supplementary Fig. 9f). The gene discussed is NFKB1; the disease is neoplasm.