CFLAR and neoplasm: In turn, c-FLIP regulates important processes maintaining immune system homeostasis: it protects mature T lymphocytes from activation-induced cell death15, it controls Treg homeostasis16 and survival from FasL-mediating killing by tumor endothelium17, as well as Fas sensitivity of monocytes and monocyte-derived cells, such as dendritic cells (DCs) and macrophages18,19 and their viability in the bone marrow during normal development20.