TP53 and non-small cell lung carcinoma: In the FHC-overexpressing NSCLC cells (A549pc3FHC and H460pc3FHC) we observed a down-regulation of miR-125b accompanied by a roughly two-fold increase of p53 protein expression; these effects were counteracted when miR-125b levels were restored in the A549 and H460 cells co-transfected with pc3FHC and miR-125b mimic (A549pc3FHC/miR-125b mimic and H460pc3FHC/miR-125b mimic) (P < 0.05; Fig. 3a, b).