Disabled homolog 2-interacting protein (DAB2IP), Smad7, reversion inducing cysteine rich protein with Kazal motifs (RECK), Dikkopf-3 (DKK3) and Smad3 have been identified as targets of miR-92b-3p and responsible for the promotion of cell proliferation and invasion in bladder cancer, hepatocellular carcinoma, osteosarcoma, glioma and glioblastoma, respectively [24, 25, 27–29]. Here, SMAD3 is linked to hepatocellular carcinoma.