To further confirm whether AKT phosphorylation induced by HCRP-1 suppression led to the negative expression of BIM in HCT116 and SW620 cells, we added the AKT-specific inhibitor, MK-2206 (10 mM/L) into CRC cells transfection with siRNA for HCRP-1. This evidence concerns the gene BCL2L11 and colorectal carcinoma.