These age-related genes also included several known neurodevelopmental genetic risk loci implicated in ASD (LRP1, RNF135, YWHAE), schizophrenia (TEKT4, LRP1, DNAH1, BRSK1, INTS1, ZC3H10, METTL14), and developmental delay (SCYL1, PIGQ, OBSL1, SMARCB1, CEP135, SPG11, TAF1, TAT, FAM126A, RAD21). Here, SPG11 is linked to Global developmental delay.