These age-related genes also included several known neurodevelopmental genetic risk loci implicated in ASD (LRP1, RNF135, YWHAE), schizophrenia (TEKT4, LRP1, DNAH1, BRSK1, INTS1, ZC3H10, METTL14), and developmental delay (SCYL1, PIGQ, OBSL1, SMARCB1, CEP135, SPG11, TAF1, TAT, FAM126A, RAD21). This evidence concerns the gene RNF135 and Global developmental delay.