Several significant age-related proteins mapped to known neurodevelopmental genetic risk loci, including genetic loci implicated in autism spectrum disorder (ASD) (ANK2, YWHAE, L1CAM, FABP5, NRCAM), intellectual disability (L1CAM, PLP1, PSAP, QDPR), and schizophrenia (NCAN, ALCAM, GNAO1, PSAP, NFASC). The gene discussed is PSAP; the disease is Intellectual disability.