Inhibition of neutrophil recruitment (e.g., with small molecule CXCR2 inhibitors) and NETosis has shown benefit in murine tumour models.28,29,49 Coffelt et al.50 showed in a mammary tumour model that tumour-induced neutrophils suppressed CTL responses, and depletion of IL-17 or G-CSF abrogated the T-cell suppressive phenotype of neutrophils. The gene discussed is CSF3; the disease is neoplasm.