HLA-A and Miyoshi myopathy: Several groups have developed engineered TCR and mTCR-CAR approaches to target NY-ESO-1, which was found to be highly expressed in poor-prognosis MM.85–90 Maruta et al.85 developed an mTCR-CAR T cell specific for an NY-ESO-1 that was presented by a HLA-A*02:01 molecule, and which showed significant anti-MM reactivity.