In addition, it is interestingly to note that CNV of the pathway downstream members represented by RPS6 and 4EBP1 genes, respectively involved in cap-dependent translation and ribosome biogenesis [32, 46], occurred in mutually exclusive manner; thus suggesting that SS patients may cluster respect to these gene alterations leading toward different routes of protein synthesis. This evidence concerns the gene EIF4EBP1 and synovial sarcoma.