Considering the trafficking ability of SS cells [23, 37, 39] these genomic dysfunctions promoting aerobic glycolysis and protein translation might be functionally useful, in term of energy, during the SS cells recruitment to skin and/or lymph node by SDF-1 and CCL21, both able in turn, to promote mTORC1 activation signaling and proliferation of these cells. This evidence concerns the gene CXCL12 and synovial sarcoma.