The largest observed multimorbid cluster (Supplementary Fig. 4, cluster#6) is an outgroup of phenotypes located in the bottom left hand corner of the matrix that highlights interrelationships among polyunsaturated fatty acids (PUFAs), Crohn’s disease, inflammatory bowel disease, colorectal cancer, laryngeal squamous carcinoma, insulin sensitivity, comprehensive strength index, and cholesterol levels (Fig. 2a). The gene discussed is INS; the disease is colorectal cancer.