TP53 and neoplasm: Furthermore, GSEA of biological pathways comparing the mouse metastasis progression signature with the MSigDB Hallmarks dataset revealed a significant enrichment of pathways that are commonly associated with metastatic progression in other tumor contexts, including epithelial to mesenchymal transition, E2F targets, Myc targets, TGF beta, and P53 pathway among others (p < 0.05; Fig. 2e; Supplementary Data 2).