NSD2 and Wolf-Hirschhorn syndrome: NSD2 was discovered as the overexpressed product of the t(4;14)(p16.3;q32.3) translocation in multiple myeloma, and alternatively named Multiple Myeloma SET domain containing protein (MMSET), and was identified as a target gene on the 4p16 deletion for the Wolf-Hirschhorn Syndrome, and alternatively called Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1)53.