Furthermore, when engrafted in vivo, these MR-silenced NPK cells displayed reduced tumor growth (p < 0.05, two-way ANOVA) and/or reduced incidence of metastasis compared with the control cells, also to varying degrees for each MR (p < 0.05, two-tailed Student's t-test; Supplementary Fig. 3e–g). The gene discussed is NR3C2; the disease is neoplasm.