To consider whether it might be feasible to pharmacologically target NSD2 activity to inhibit prostate cancer progression and tumor growth, we used a small molecule inhibitor of NSD2 called MCTP-39 (3-hydrazinoquinoxaline-2-thiol), which has been reported to be a lysine-HMTase inhibitor that is a competitor of the SAM (Sterile Alpha Motif) domain56. This evidence concerns the gene NSD2 and Familial prostate cancer.