In vitro, uPARAP was also expressed by human LECs (HMVEC) under basal conditions and its level of expression was stimulated in the presence of medium conditioned by different tumor cells derived from human skin carcinomas (HaCat A5-RT3, HaCaT II4 cells), murine mammary carcinoma (PyMT cells), human breast carcinoma (MDA-MB231 cells), human cervical carcinoma (CaSki), and human lung carcinoma (A549) (Fig. 3b). This evidence concerns the gene MRC2 and breast carcinoma.