The absence of PTV, Mis3, Mis2, or Mis1 variants in our controls overestimated the strength of the association of ACPP, ERI3, and PLCXD3 variants with BD in our data but appears to be consistent with the extremely low TAC/ANmax ratio in ExAC NFE data (Table 3). The gene discussed is PLCXD3; the disease is Behcet disease.