To conclude, this study for the first time demonstrated that UCA1 regulating the malignant behaviors of glioma cells by targeting transcription factor NR2C2 is mediated by miR-627-5p and eventually affects the expression of downstream protein SPOCK1, but NR2C2-47aa-uORF regulated the expression of NR2C2 directly to impair the effect of this feedback loop (Supplementary Fig. 1d). Here, NR2C2 is linked to central nervous system cancer.