If the chromosomes most frequently affected by copy-number gains were considered (i.e., chromosome 10p, 8/8q, and 17q2–5), the following GISTIC segments may assume importance: 10p15.1 with 19% of SS tumors affected (4/21) spanning PRKCQ gene, 8q24.13, altering 62% of cases (13/21 and 3/3 cell lines) encompassing two genes, one of which is MYC, already cited as candidate gene in SS2, and 17q12, involving 52% of tumors (11/21 and 2/3 cell lines), where the GISTIC peak falls in close proximity of an uncharacterized open- reading frame (C17orf102) (Fig. 1). The gene discussed is PRKCQ; the disease is synovial sarcoma.