ZEB1 and neoplasm: To test this hypothesis, we compared the fraction of tumor genome affected by SCNAs for nine SS samples with ZEB1 homo-deletions or strong mRNA under expression and eight SS tumors with ZEB1-positive expression calculated as the proportion of genome altered (PGA) described by Thu KL et al.36 No significant results were found considering either all lesions (i.e., gains and losses) or losses and gains taken separately (Supplementary Figure S5), thus, ZEB1 depletion does not seem to increase genetic instability in SS.