We analyzed HLA class I/HBV epitope complex expression on target cells with HBV DNA integration: HepG2.2.15 (HepG2 cells with full HBV genome integration) (10), HepG2-Env (HepG2 cells with full HBV genotype D envelope) (35), and PLC/PRF5/HLA-A2+ (natural HCC line with partial HBV surface antigen DNA integration [36] transduced with the HLA-A*02:01 molecule) cells. Here, HLA-A is linked to hepatocellular carcinoma.