Though this scenario had been entertained for both human (Al‐Dosari et al, 2013; Saugier‐Veber et al, 2017) and murine (Feldner et al, 2017) MPDZ‐linked hydrocephalus, no direct causative connection has been established between possible MPDZ LOF deleterious effects on intercellular junction integrity and the formation of hydrocephalus in humans or mice carrying MPDZ LOF mutations. The gene discussed is MPDZ; the disease is Hydrocephalus.