To determine the dependence of the barrier function of CPEC monolayers on Mpdz, we compared the time course of impedance, an established permeability surrogate (Bischoff et al, 2016), of human papilloma CPEC (hpCPEC) monolayers (Ishiwata et al, 2005; Feldner et al, 2017) transduced by MPDZ‐targeting or by non‐targeting shRNA. The gene discussed is MPDZ; the disease is papilloma.