VHL and renal cell carcinoma: We and others have shown AURKA is elevated in VHL-deficient RCC (Dere et al., 2015; Hasanov et al., 2017; Lolkema et al., 2008; Thoma et al., 2007), and our recent finding identified AURKA as a target of E3 ligase activity of VHL (Hasanov et al., 2017), providing a direct link between elevated AURKA and VHL-null RCC.