Higher skewness and lower kurtosis were also significantly associated with the presence of a K-ras mutation in non-small cell lung cancer in the study of Weiss et al. [27] However, in the present study, there was no statistically significant difference in skewness and kurtosis between different tumor risk levels, reflecting a limited role of skewness and kurtosis in the risk stratification of small bowel-GISTs. This evidence concerns the gene KRAS and neoplasm.