NEU1 and Global developmental delay: However, it is tempting to speculate that NEU1 activity-dependent desialylation of glycoproteins on the neuronal surface may interfere with sialic acid signaling-dependent neural activities, including synaptic plasticity [55, 56], hippocampal memory [55, 56], neurotransmission, neural cell adhesion [55–57], and AMPA receptor trafficking [57, 58], and was associated with epilepsy [11, 59, 60], developmental delay, and neuropsychiatric disorders [56, 57, 61] such as schizophrenia and bipolar disorder observed in the patients with neonatal white matter injury.