LCAT and coronary artery disorder: Most recently, in a prospective cohort study carried out in the general population in Japan, a positive correlation was observed between the LCAT activity, measured in terms of the serum cholesterol esterification rate assessed by the endogenous substrate method, and the serum levels of the TRLs, and the group with elevated LCAT activity showed a significantly higher incidence of sudden death and coronary artery disease [24].