Par-4 contains two nuclear localization sequences (NLS1 and NLS2), a VASA domain (a sequence similar to that found in the VASA protein), a selective for apoptosis induction in cancer cells (SAC) domain, a coiled coil (CC) domain with a leucine zipper (LZ), and a nuclear export sequence (NES) [2,5,17]. The gene discussed is PAWR; the disease is cancer.