Three main APOE alleles have been identified: ApoE-2 (Cys112, Cys158), ApoE-3 (Cys112, Arg158), and ApoE-4 (Arg112, Arg158); the small differences derived from these two amino acid positions have relevant consequences in the structure and function of Apo-E, thereby modulating the prognosis and progression of cardiovascular disease. This evidence concerns the gene APOE and cardiovascular disorder.