Some studies have estimated that carriers of the ApoE-ԑ4 allele may have a 42% higher risk of cardiovascular disease than carriers of the ApoE-ԑ3/ԑ3 genotype; they also have a greater risk of Alzheimer’s disease, and in general the genotype is negatively associated with longevity [118,119,120]. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.