Notably, in liver diseases such as PBC [95], MFs, and RDCs express high levels of Hh that could act in an autocrine/paracrine manner on surrounding cells and MFs itself further stimulating the proliferation of BECs, through the upregulation of PDGF-B signaling in an (Protein Kinase B Alpha) Akt-dependent fashion [96]. Here, AKT1 is linked to primary biliary cholangitis.