In ADPKD, the proliferation of liver cysts both in human and in animal models of PC2 conditional KO mice, VEGF-A is hyper-secreted by BECs and stimulates liver cyst enlargement in an autocrine fashion through a VEGFR2/(Mitogen-Activated Protein Kinase Kinase 1) MEK/(Extracellular Signal-Regulated Kinase) ERK1/2/(Mammalian Target Of Rapamycin) mTor axis [66,70,71]. This evidence concerns the gene MAP2K1 and Hepatic cysts.