None of the five proteomic studies that analyzed whole spinal cord extracts from mouse or rat models of ALS reported detection of calreticulin [49,52,54,55,56] (Table S1) (but this is perhaps not surprising since each of these studies utilized a 2D-gel electrophoresis protocol which identifies significantly fewer proteins compared to more recent techniques such as iTRAQ or label-free quantification). The gene discussed is CALR; the disease is amyotrophic lateral sclerosis.