In proteomic studies of ALS, calreticulin was found to be increased in the ventral roots from the spinal cord of ALS SOD1G93A mice [50], blood mononuclear cells from ALS patients [48], and in TDP-43 knockdown SH-SY5Y cells [44], and in agreement with this, we also found increased levels of calreticulin in spinal cord extracts from late-symptomatic ALS SOD1G93A mice. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.