ENO1 and breast cancer: MBP-1 can inhibit the expression of c-Myc by binding to the P2 promoter of c-Myc and also inhibit the expression of COX-2 and ERBB2. As shown in Figure 3, MBP-1 can affect the regulation of PI3K/AKT pathway by inhibiting the expression of the ERBB2 gene in the breast cancer cells (SKBr3 cell line), thus suppressing cell apoptosis [47].