MYC and cancer: In vertebrates, MBP-1 suppresses tumorigenesis and regulates the growth and metastasis of cancer cells by regulating genes expression, such as c-MYC, COX-2 and ERBB2. Arabidopsis plants that the overexpression of AtMBP-1 are hypersensitive to abscisic acid (ABA) during seed germination and show defects in vegetative growth and lateral stem development.