The research has also illustrated that MBP-1 suppresses the activity of endothelin-1 (ET-1), angiogenin (ANG), interleukin-8 (IL-8), MMP-9, placental growth factor (PGF) and vascular endothelial growth factor (VEGF), which all accelerate cell apoptosis in breast cancer cells (MCF-7) [50]. Here, EDN1 is linked to breast cancer.