The exogenous expression of MBP-1 in NSCLC cells inhibits cell proliferation and induces mitochondrial pore formation which does not allow accumulation of cytochrome C. MBP-1 also increases the causes of necrosis-like cell death in the NSCLC cell line, H1299 cells, including cellular densification with highly disorganized nuclei, numerous small and large cytoplasmic vacuoles, lipid droplets, extensive cell lysis with accompanying cellular debris and numerous swollen and internally disorganized mitochondria. This evidence concerns the gene ENO1 and non-small cell lung carcinoma.