ENO1 and cancer: Several studies revealed that as a potent plasminogen-binding protein, α-ENO is expressed in a variety of cell surfaces (T cells, B cells and neurons) and is also related to the pathogenic effects of many diseases, including cancer, Alzheimer’s disease and rheumatoid arthritis [25]; α-ENO can also affect the physiological metabolism, apoptosis and migration of cancer cells and is expected to be a novel pharmacological target or immunotherapeutic strategy for cancer treatment [10,26].