A recent prospective study on 9856 BRCA1 or BRCA2 mutation carriers reported a cumulative risk of BC and OC to age 80 years of 72% and 44%, respectively, for germline BRCA1 mutations and, 69% and 17% in case of germline BRCA2 mutations [6] These data are consistent with findings from retrospective family-based studies [7]. This evidence concerns the gene BRCA1 and breast cancer.