PARP1 and breast cancer: Finally, in 2018, olaparib as well as talazoparib (highly potent PARP1 and PARP2 inhibitor clinically active at 1 mg dose; Talzenna, Pfizer, New York, NY, USA) were FDA approved for patients with epidermal growth factor receptor 2 (HER2)-negative metastatic BC with BRCA mutations, relapsing after previous chemotherapy in the neoadjuvant, adjuvant, or metastatic setting [59,60] (Table 1).