Epigallocatechin-3-gallate (EGCG), a polyphenol in green tea, also proved to have neuroprotective impact in cases of cerebral ischemia in rats in vivo [129], a finding that applied also to quercetin, which protected the integrity of the blood-brain barrier in rats where it was administered intraperitoneally by reducing levels of matrix metallopeptidase 9 (MMP-9) [130]. The gene discussed is MMP9; the disease is brain ischemia.