NR3C1 and neoplasm: These immunohistochemical findings in bladder cancer specimens, along with the down-regulation of the GR expression in the urothelial tumors (vs. the non-neoplastic urothelial tissues) and the muscle-invasive tumors (vs. the non-muscle-invasive tumors), strongly suggest a protective/inhibitory role of the GR signals in urothelial tumorigenesis and tumor growth.