In the other study [41], however, dexamethasone at 10–1000 nM, significantly induced the growth of GR-positive human bladder cancer lines, TCCSUP, and UMUC3, compared with mock treatment, but not that of their GR knockdown sublines derived following an infection with the GR-short hairpin RNA (shRNA) virus, and the stimulatory effects of dexamethasone on cell proliferation were blocked by RU486 which functions as an GR antagonist. This evidence concerns the gene NR3C1 and urinary bladder cancer.