Indeed, dexamethasone was found to induce both transactivation (i.e., induction of the GRE-mediated transcriptional activity and the expression of FKBP51 and GILZ genes) and transrepression (i.e., suppression of the NF-κB and AP-1 transcriptional activities and the expression of NF-κB-regulated genes, such as interleukin (IL)-6, matrix metalloproteinase (MMP)-2, MMP-9, and vascular endothelial growth factor (VEGF)) of GR in the bladder cancer cells [44]. This evidence concerns the gene MMP2 and urinary bladder cancer.