As the down-regulation of GR expression in surgical samples of bladder tumor is strongly associated with the risks for recurrence of a non-muscle-invasive disease, following transurethral tumor resection, and progression of a muscle-invasive disease, following radical cystectomy, GR is thought to function generally as a tumor suppressor for urothelial cancer. Here, NR3C1 is linked to urinary bladder neoplasm.