Besides incorporating the dietary recommendations, nutrients and foods related to various aging related health outcomes and involved in chronic inflammation have been taken into account when designing the NU-AGE diet, including MUFA, PUFA, olive oil or oily fish (inflammatory processes [5] and inflammatory bowel diseases [63]), protein (sarcopenia [7]), vitamin D (falling [8]), vitamin B12 (cognitive impairment [9]), vitamin C and fruit (CRP [11]), and whole grains (type 2 diabetes [64], cardiovascular disease [65], BMI [66], and blood lipids [67]). This evidence concerns the gene CRP and Cognitive impairment.