CXCR4 and obesity due to melanocortin 4 receptor deficiency: CCR2 and CX3CR1 have been implicated in adipose regulation via their effects on macrophage infiltration into adipose tissue and the subsequent regulatory role of these cells.30, 31 CXCR4 is expressed on adipocytes and limits obesity, demonstrated by CXCR4 adipocyte‐specific KO mice displaying exaggerated high fat diet‐induced obesity, compared to WT mice.35 This study suggested that CXCR4 played a role in limiting inflammatory cell infiltration into adipose tissue but also in the thermogenic activity of brown adipose tissue.