Moreover, disruption of Mef2d andMef2c pathways has been linked to amyotrophic lateral sclerosis(Arosio et al., 2016), and aberrantactivation was shown to mediate neuronal death in mouse and fly models of Friedreichataxia (Chen et al., 2016a, 2016b), indicating their potential role inneurodegeneration. Here, MEF2D is linked to amyotrophic lateral sclerosis.