Likewise, resistance properties to anti-tumor therapy are associated with SOX2-mediated activation of multidrug resistance ABC transporter genes (Dean et al., 2005) because their protein products are able to efflux drugs across the cell membrane by utilizing ATP in glioblastoma (Jeon et al., 2011), HNSCC (Lee et al., 2014), gastric cancers (Tian et al., 2012), and breast cancers (Figure 2C) (Mukherjee et al., 2017). This evidence concerns the gene SOX2 and breast cancer.