In CSCs, SOX2-mediated drug resistance was acquired through activation of EMT pathway in CRC (Han et al., 2012), HNSCC (Lee et al., 2014), PDAC (Herreros-Villanueva et al., 2013), and breast cancers (Mukherjee et al., 2017). The gene discussed is SOX2; the disease is head and neck squamous cell carcinoma.