SOX2 and gastric cancer: CSC in gastric cancers had been reported recently (Chen et al., 2012; Tian et al., 2012) and SOX2 had been implicated in maintaining stem-like properties of gastric cancer cells and enhanced chemoresistance to cisplatin or Adriamycin, possibly via upregulation of ABC drug transporters (MRP2 and MDR1) (Tian et al., 2012).