In LSCC mouse model mimicking human LSCC, Mukhopadhyay et al. (2014) showed that lung-specific Lkb1 loss in association with enforced overexpression of SOX2 could drive formation of tumors with solely squamous morphology (LSCC), while the expression of SOX2 in the context of Trp53 loss, either alone or in co-ordination with Rb loss, could induce lung adenocarcinoma (LADC). This evidence concerns the gene SOX2 and lung adenocarcinoma.